Ole Miss vs. Vanderbilt odds, line, spread: 2021 college football picks, Week 12 predictions from proven model

The Ole Miss Rebels and the Vanderbilt Commodores are set to square off in an SEC matchup at 7:30 p.m. ET on Saturday at Vaught-Hemingway Stadium at Hollingsworth Field. The Rebels are 8-2 overall and 6-0 at home, while Vanderbilt is 2-8 overall and 1-2 on the road. Ole Miss has dominated this series in recent years, winning six of its last eight meetings against the Commodores. 

The Rebels are favored by 36.5-points in the latest Ole Miss vs. Vanderbilt odds from Caesars Sportsbook, and the over-under is set at 64.5. Before entering any Vanderbilt vs. Ole Miss picks, you’ll want to see the college football predictions from the proven computer model at SportsLine.

The SportsLine Projection Model simulates every FBS college football game 10,000 times. Over the past five-plus years, the proprietary computer model has generated a stunning profit of almost $3,500 for $100 players on its top-rated college football picks against the spread. It also enters Week 12 of the 2021 season on a 36-23 run on all top-rated college football side picks. Anyone who has followed it has seen huge returns.

Now, the model has set its sights on Ole Miss vs. Vanderbilt. You can head to SportsLine to see its picks. Here are several college football odds for Vanderbilt vs. Ole Miss:

  • Ole Miss vs. Vanderbilt spread: Ole Miss -36.5
  • Ole Miss vs. Vanderbilt over-under: 64.5 points

What you need to know about Ole Miss

Ole Miss had a touchdown and change to spare in a 29-19 win over the Texas A&M Aggies last Saturday. Running back Jerrion Ealy was the offensive standout of the game for Ole Miss, picking up 150 yards on the ground on 23 carries. For the season, Ealy has recorded 96 carries for 588 yards and four touchdowns. He’s averaging 6.1 yards per carry this season. 

Led by Heisman contender Matt Corral at quarterback, the Rebels enter Saturday’s showdown averaging 522.2 yards per game on offense, which ranks third in the nation. Ole Miss has also won each of its last eight home games, and the Rebels are 4-1 against the spread in their last five meetings against an opponent from the SEC East.

What you need to know about Vanderbilt

Meanwhile, Vanderbilt lost to the Kentucky Wildcats last Saturday by a 34-17 final. The Commodores were down 31-11 at the end of the third quarter, which was just too much to recover from. No one had a standout game offensively for Vanderbilt, but the Commodores got scores from receivers Chris Pierce Jr. and Amir Abdur-Rahman.

Vanderbilt is on a five-game losing streak and the Commodores have lost seven of their last eight overall. However, Vanderbilt is 8-3 against the spread in its last 11 games on the road against Ole Miss.  

How to make Vanderbilt vs. Ole Miss picks

The model is leaning under on the total, and it’s also generated a point-spread pick that is hitting in well over 50 percent of simulations. You can only see the pick at SportsLine.

So who wins Ole Miss vs. Vanderbilt? And which side of the spread hits well over 50 percent of the time? Visit SportsLine now to see which side of the spread to jump on, all from the advanced model that has crushed its college football picks

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